Today's opponents, the Chicago Cubs, hold the record for most runs scored before plunking Craig Biggio in a game. On August 20, 2002 Kyle Farnsworth hit Biggio with a pitch while the Cubs were leading 13-8 in the seventh inning. Biggio scored one of three Astros runs in that inning, but it wasn't enough for the Astros to get the win.
Biggio has been hit 9 times while trailing the Cubs, 7 times while in the lead against them, and 3 times while the teams were tied. The 2 of the 5 times Biggio has been plunked while trailing by 6 runs have been against the Cubs, as well as 2 of the 5 times he's been hit while behind by 5 runs.
Craig Biggio has been hit by a pitch a total of 91 times during tied ballgames. 96 plunks came while the Astros were winning, and 90 were thrown when the Astros were trailing in the game. 224 of his 277 plunks have been at points in the game when the Astros were within 3 runs (in either direction) of their opponent.
The biggest deficit he's been plunked at is 9 runs, but he's done that twice. The biggest lead he's had when he was hit by a pitch is ten runs.
Biggio has been hit most often when the game is scoreless - 63 times. Following that, a 1-0 Astros lead is his next most frequently plunked score, with 14.
Pedro Astacio and Mark Gardner have each hit Craig Biggio with a pitch 3 times when the game was scoreless. 5 other pitchers have plunked Biggio twice with a 0-0 score, but no pitcher has ever plunked Biggio on two different occasions with the scoreboard at anything other than 0-0.
Plunks, and runs scored off them, by Astros' lead:
Total plunks by score:
(note: these scores are as of the time Biggio was hit, not final game scores)